A 12-year-old boy has contracted a bacterial infection at school and his body has responded by increasing leukocyte production. Place the following components of white blood cell production in the correct chronological order. Use all the options.
A) Myeloblast
B) Promyelocyte
C) Myeloid stem cell
D) Metamyelocyte
E) Neutrophil
2. Which of the following statements most accurately conveys an aspect of lymphatic system activity?
A) B and T lymphocyte development begins in the bone marrow and ends in the peripheral lymphoid structures.
B) B cells and macrophages are released from the bone marrow in their completed state.
C) Stem cells in the lymph nodes initiate and regulate the process of white cell synthesis.
D) Leukocytes bypass vascular circulation and are distributed instead by the lymphatic system.
3. A 44-year-old male hospital patient with a diagnosis of end-stage acquired immunodeficiency syndrome (AIDS) has been placed on neutropenic precautions that limit his interaction with visitors, staff, and other patients. What is the underlying rationale for these precautions?
A) His antibody-mediated immunity is compromised by his low production of neutrophils.
B) Neutropenia limits the ability of his CD4 helper cells to present antigens.
C) Insufficient levels of neutrophils make him particularly susceptible to bacterial and fungal infections.
D) Cyclic neutropenia limits his body’s ability to fight various infections.
4. A 16-year-old female has been brought to her primary care physician by her mother due to the girl’s persistent sore throat and malaise. Which of the following facts revealed in the girl’s history and examination would lead the physician to rule out infectious mononucleosis?
A) The girl has a temperature of 38.1°C (100.6°F) and has enlarged lymph nodes.
B) Her liver and spleen are both enlarged.
C) Blood work reveals an increased white blood cell count.
D) Chest auscultation reveals crackles in her lower lung fields bilaterally.
5. A 14-year-old boy has been diagnosed with infectious mononucleosis. Which of the following pathophysiological phenomena is most responsible for his symptoms?
A) The Epstein-Barr virus (EBV) is lysing many of the boy’s neutrophils.
B) Viruses are killing some of his B cells and becoming incorporated into the genomes of others.
C) The EBV inhibits the maturation of white cells within his peripheral lymph nodes.
D) The virus responsible for mononucleosis inhibits the maturation of myeloblasts into promyelocytes.
6. A 60-year-old woman is suspected of having non-Hodgkin lymphoma (NHL). Which of the following aspects of her condition would help to rule out Hodgkin lymphoma?
A) Her neoplasm originates in secondary lymphoid structures.
B) The lymph nodes involved are located in a large number of locations in the lymphatic system.
C) The presence of Reed-Sternberg cells has been confirmed.
D) The woman complains of recent debilitating fatigue.
7. A 40-year-old male patient is shocked to receive a diagnosis of mature B-cell lymphoma and is doing research on his diagnosis on the Internet. Which of the following statements that he reads on various Web sites is most reliable?
A) “Like most forms of Hodgkin lymphoma, mature B-cell lymphoma often requires radiation treatment.”
B) “Doctors are able to diagnose mature B-cell lymphoma by the presence of Reed-Sternberg cells.”
C) “Unlike many other lymphomas, mature B-cell lymphoma is often self-limiting and treatment is focused on symptoms.”
D) “The lymph nodes are usually affected, and often the spleen and bone marrow.”
8. Which of the following statements by a patient of a cancer center who has a new diagnosis of non-Hodgkin lymphoma (NHL) demonstrates a sound understanding of the diagnosis and treatment of the health problem?
A) “They confirmed my diagnosis with a lymph node biopsy and I’ll get radiation treatment soon because it’s in a fairly early stage.”
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